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Figure 8 | Molecular Cancer

Figure 8

From: The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

Figure 8

HOTAIR target genes are highly tissue-specific. (a) Publicly available ChIP data published by Gupta et al. [15] was used to select 674 genes gaining increased H3K27 trimethylation at promoters following ectopic expression of HOTAIR in MDA-MB-231 breast cancer cells. These were matched with 784 genes that were downregulated in both UC cell lines after stable ectopic expression of HOTAIR (p < 0.01). (b) Venn diagram for differentially expressed HOTAIR target genes in the esophageal cancer cell line KYSE180 [21] and the two UC cell lines VM-CUB1 and 5637 (p < 0.01) illustrating the minimal overlap of HOTAIR regulated genes between the two cancer types.

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