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Table 2 Univariate and multivariate analysis for HOTAIR expression and DSS of patients from UC Set 2 (n = 108)

From: The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

Variables Disease-specific survival
  HR 95% CI P
Univariate analysis    
Age (≤60 vs > 60 years) 0.923 0.562 - 1.516 0.753
Gender (male vs female) 0.697 0.407 - 1.195 0.190
Tumor stage (Ta-T1 vs T2-T4) 5,401 2.321 - 12.568 <0.001
Grade (G1- G2 vs G3) 4,237 2.203 - 8.150 <0.001
Lymph node metastasis (yes vs no) 4,884 2.832 - 8.422 <0.001
HOTAIR expression > 75% (high vs low) 2,033 1.180 - 3.501 0.011
Multivariate analysis    
Stage (T2-T4) 2,654 1.021 - 6.856 0.045
Grade (G3) 2,327 1.115 - 4.854 0.024
Lymph node metastasis (N+) 2,951 1.661 - 5.242 <0.001
HOTAIR expression (>75%) 2,200 1.232 - 3.928 0.008
  1. Abbreviations: DSS- disease-specific survival; HR hazard ratio, CI confidence interval.
  2. Patients were dichotomised according to their HOTAIR expression level (group 1 = 25% of patients with highest HOTAIR expression, group 2 = 75% of patients with average or low HOTAIR expression).