The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells

Table 2 Univariate and multivariate analysis for HOTAIR expression and DSS of patients from UC Set 2 (n = 108)

*Variables*	Disease-specific survival
	HR	95% CI	P
Univariate analysis
Age (≤60 vs > 60 years)	0.923	0.562 - 1.516	0.753
Gender (male vs female)	0.697	0.407 - 1.195	0.190
Tumor stage (Ta-T1 vs T2-T4)	5,401	2.321 - 12.568	<0.001
Grade (G1- G2 vs G3)	4,237	2.203 - 8.150	<0.001
Lymph node metastasis (yes vs no)	4,884	2.832 - 8.422	<0.001
HOTAIR expression > 75% (high vs low)	2,033	1.180 - 3.501	0.011
Multivariate analysis
Stage (T2-T4)	2,654	1.021 - 6.856	0.045
Grade (G3)	2,327	1.115 - 4.854	0.024
Lymph node metastasis (N+)	2,951	1.661 - 5.242	<0.001
HOTAIR expression (>75%)	2,200	1.232 - 3.928	0.008

Abbreviations: DSS- disease-specific survival; HR hazard ratio, CI confidence interval.
Patients were dichotomised according to their HOTAIR expression level (group 1 = 25% of patients with highest HOTAIR expression, group 2 = 75% of patients with average or low HOTAIR expression).

ISSN: 1476-4598