Aurora kinase A in gastrointestinal cancers: time to target

Table 1 Selected cancer associated proteins regulated by AURKA

Protein	Type of regulation	Functional significance	References
p53	Phospho-Ser215	Abrogates transactivation	[48,56]
p53	Phospho-Ser315	Abrogates transactivation and enhances proteasomal degradation	[48,56]
NF-κBp65	Phospho-Ser536	Promotes inflammation and cell survival	[49]
P73	Phospho-Ser235	Induces apoptosis	[52-56]
MDM2	Phospho-Ser166	Activates MDM2 and degradation of P53	[48]
GSK3β	Phospho-Ser9	Inhibits GSK3β and enhances β-catenin activity	[19]
IκBα	Phospho-Ser32	Induces degradation of IκBα and activation of NF-κB pathway	[49]
JAK2	Increased expression	Activates STAT3	[55]
N-MYC	Increased expression	Stabilizes N-MYC protein	[106]
SRC	Phospho-Tyr416	Activates SRC and promotes cancer cell invasion	[18]
IKKα/β	Phospho-Ser176/180	Activates NF-κB pathway	[107]
NF-κB2/p100	Phospho-Ser866/870	Activates non-canonical NF-κB pathway	[108]
STAT3	Phospho-Tyr705	Promotes cell survival	[55]
RalA	Phospho-Ser194	Enhances transformed cell growth	[74]
BRCA1/BRCA2	Decreased expression	Down-regulate cell cycle and DNA damage response	[16,17,109]

ISSN: 1476-4598