Fig. 1

Intra-peritoneal injection of Imetelstat efficiently inhibits telomerase and reduces tumor growth. a Experimental design: mice were xenografted and intra-peritoneal injections were started three days later, either with Imetelstat (30 mg/Kg three times a week) or by an equivalent volume of PBS. Tumor volume was determined by μMRI at day 28, and the treatment was maintained until the mice were sacrificed (when tumor growth was predicted to be about 70 mm³ by the μMRI imaging). b Tumor volume at day 28 is significantly reduced by Imetelstat (IMT) treatment versus PBS (Wilcoxon test). c Intra-peritoneal injection of Imetelstat is able to significantly reduce the TA inside the tumor (Wilcoxon test). d TA and tumor volume are correlated (Spearman test), the grey and black circles correspond respectively to the mice treated by IMT or by PBS