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Fig. 4 | Molecular Cancer

Fig. 4

From: Anticancer effect of tectochrysin in colon cancer cell via suppression of NF-kappaB activity and enhancement of death receptor expression

Fig. 4

Structural interaction between tectochrysin and NF-κB. a Structure of tectochrysin. b Pull-down assay identifies an interaction between the tectochrysin and NF-κB p50. Tectochrysin was conjugated with epoxy-Sepharose 6B as described in Methods. c Docking model of tecotochrysin with NF-κB p50 as described in Methods. d The p50 mutant cells were treated tectochrysin for 24 h, and then analyzed by MTT assay. The data are expressed as the mean ± SD of three experiments. *P < 0.05 compared with the untreated control. #P < 0.05 compared with treated control. e SW480 colon cancer cells were transiently transfected with control or mutant types of p50 for 24 h as described in Methods, and then the cells were treated with tectochrysin for 1 h to determine DNA binding activity of NF-κB. Values below the band are average of band density

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