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Fig. 4 | Molecular Cancer

Fig. 4

From: Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

Fig. 4

Design of the orthotopic RCC model and humanization with PBMC. (a) Diagram of the orthotopic implantation and engraftment of a human RCC line, transduced with luciferase, into the subrenal capsule of NSG mice. Subsequent to tumor engraftment, human PBMC and then anti-CAIX or control IgG1 treatment was administered to mice intravenously, with repeated dosing of treatment and measurement of tumor growth by BLI every 3–4 days. (b) Outline of establishment and treatment of the orthotopic model

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Molecular Cancer

ISSN: 1476-4598