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Fig. 8 | Molecular Cancer

Fig. 8

From: Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo

Fig. 8

Histological analysis of immune infiltrates in orthotopic RCC tumors. (a) Immunohistochemical detection of Ly6G+, human CD3+, or human PD-1+ cells in the tumor sections at day 14 (upper panels) and day 32 (lower panels) of indicated treatment group. Large panels represent a 10x magnification of the indicated treatment group (rows) for detection of each marker (columns), with the smaller inset of 2x magnification indicating the magnified area. In each magnification, “K” indicates the mouse kidney and “T” represents the orthotopic tumor. Bars scale, 150 μm and 750 μm for 10x and 2x magnification, respectively. (b) The cell numbers per mm2 were measured in the tumor sections by Aperio and ImageScope software from at least three sections of each tumor in the indicated treatment group. * indicates p value of student t-test < 0.05, compared to control IgG1

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