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Table 1 Clinico-pathological characteristics of cervical specimens and PCR-based analysis of their genomic DNA for HPV infection and genotype analysis

From: Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis

Tissue type Characteristics Number of samples Total HPV+ (HPV L1) (n/%age) HPV 16 (n/%age) HPV18 (n/%age) Others HPV (n/%age) Multiple infections
Normal/Control   23 1 (4.3 %) 1 (4.3 %) - - -
Cytolgically normal 3 - - - - -
Cervicitis 20 1 (5 %) 1 (5 %) - - -
Pre-cancer   23 14 (61 %) 12 (52 %) 1 (4.3 %) 0 -
LSIL 10 5 (50 %) 4 (40 %) 0 0 -
HSIL 13 9 (69 %) 8 (62 %) 1 (7.7 %) 0 -
Cancer Tissues   56 53 (95 %) 44 (79 %) 6 (11 %) 4 (7.1 %) 5 (9 %)
  44a 39 (88.7 %) 33 (75 %) 6 (13.7 %) 1 (2.3 %) 5 (11.3 %)
Histopathological grading WDSCC 16 15 (94 %) 12 (75 %) 2 (13 %) 0 2 (13 %)
MDSCC 14 10 (71.4 %) 10 (71.4 %) 1 (7 %) 1 (7 %) 0
PDSCC 14 14 (100 %) 11 (79 %) 3 (21 %) 0 3 (21 %)
  52a 48 (92 %) 42 (81 %) 5 (9.6 %) 4 (7.7 %) 5 (9.6 %)
Clinical stages Stage I 5 5 (100 %) 5 (100 %) 0 0 0
Stage II 17 15 (88 %) 14 (82 %) 2 (12 %) 1 (6 %) 1 (6 %)
Stage III 26 24 (92 %) 19 (73 %) 3 (11.5 %) 1 (4 %) 3 (11.5 %)
Stage IV 4 4 (100 %) 4 (100 %) 0 2 (50 %) 1 (25 %)
  1. HPV human papillomavirus, SCC squamous cell carcinoma, LSIL low grade squamous intraepithelial lesions, HSIL high grade squamous intraepithelial lesions, WDSCC well differentiated SCC, MDSCC moderately differentiated SCC, PDSCC poorly differentiated SCC. aHistopathological grading & clinical staging were available for 44 and 52 samples respectively