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Table 1 Clinico-pathological characteristics of cervical specimens and PCR-based analysis of their genomic DNA for HPV infection and genotype analysis

From: Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis

Tissue type

Characteristics

Number of samples

Total HPV+ (HPV L1) (n/%age)

HPV 16 (n/%age)

HPV18 (n/%age)

Others HPV (n/%age)

Multiple infections

Normal/Control

 

23

1 (4.3 %)

1 (4.3 %)

-

-

-

Cytolgically normal

3

-

-

-

-

-

Cervicitis

20

1 (5 %)

1 (5 %)

-

-

-

Pre-cancer

 

23

14 (61 %)

12 (52 %)

1 (4.3 %)

0

-

LSIL

10

5 (50 %)

4 (40 %)

0

0

-

HSIL

13

9 (69 %)

8 (62 %)

1 (7.7 %)

0

-

Cancer Tissues

 

56

53 (95 %)

44 (79 %)

6 (11 %)

4 (7.1 %)

5 (9 %)

 

44a

39 (88.7 %)

33 (75 %)

6 (13.7 %)

1 (2.3 %)

5 (11.3 %)

Histopathological grading

WDSCC

16

15 (94 %)

12 (75 %)

2 (13 %)

0

2 (13 %)

MDSCC

14

10 (71.4 %)

10 (71.4 %)

1 (7 %)

1 (7 %)

0

PDSCC

14

14 (100 %)

11 (79 %)

3 (21 %)

0

3 (21 %)

 

52a

48 (92 %)

42 (81 %)

5 (9.6 %)

4 (7.7 %)

5 (9.6 %)

Clinical stages

Stage I

5

5 (100 %)

5 (100 %)

0

0

0

Stage II

17

15 (88 %)

14 (82 %)

2 (12 %)

1 (6 %)

1 (6 %)

Stage III

26

24 (92 %)

19 (73 %)

3 (11.5 %)

1 (4 %)

3 (11.5 %)

Stage IV

4

4 (100 %)

4 (100 %)

0

2 (50 %)

1 (25 %)

  1. HPV human papillomavirus, SCC squamous cell carcinoma, LSIL low grade squamous intraepithelial lesions, HSIL high grade squamous intraepithelial lesions, WDSCC well differentiated SCC, MDSCC moderately differentiated SCC, PDSCC poorly differentiated SCC. aHistopathological grading & clinical staging were available for 44 and 52 samples respectively