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Fig. 4 | Molecular Cancer

Fig. 4

From: COSMC knockdown mediated aberrant O-glycosylation promotes oncogenic properties in pancreatic cancer

Fig. 4

COSMC knockdown promotes migration and survival and inhibits proliferation in PDAC cells in vitro a Proliferation of Panc-1 COSMC knockdown cells compared to control. Proliferation was measured in MTT assay over 96 h using Panc-1 COSMC knockdown cells (black) and control cells (grey) (p < 0.001). L3.6pl COSMC knockdown and control cells are indicated as dotted line. b above: Scratch assay are displayed for Panc-1 COSMC knockdown cells compared to control at different time points. b below: HE stained transwell membranes after 24 h of Panc-1 COSMC knockdown cells (left) and control cells (right) c: Relative migration of Panc-1 and L3.6pl COSMC knockdown cells was compared to control cells using transwell assay. Migrated cells were determined after 24 h (p ≤ 0.001). d: Apoptosis rate of Panc-1 and L3.6pl COSMC knockdown cells was compared to control cells using ELISA based cleaved Caspase-3 assay. Cleaved Caspase-3 expression was determined after 24 h (p = 0.03 and 0 = 0.017)

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