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Fig. 5 | Molecular Cancer

Fig. 5

From: RETRACTED ARTICLE: HGF and TGFβ1 differently influenced Wwox regulatory function on Twist program for mesenchymal-epithelial transition in bone metastatic versus parental breast carcinoma cells

Fig. 5

Twist played a specific role in E-cadherin transactivation stimulated by HGF through PPARγ/Ets1/NF-kB activities. a, b, c, d and e The 1833 cells, transiently transfected with the E-cadherin promoter-ΔPPRE fragment, the various constructs containing the gene reporter driven by transcription-factor multimer, E-cadherin short fragments wild type (ECad-wtLuc) and E-boxes-mutated (ECad-mutLuc), or the entire E-cadherin promoter (ECadLuc), were co-transfected with ΔTwist or ΔARNT in the presence or the absence of HGF and TGFβ1. ECad-wtLuc and ECad-mutLuc structures are shown. The histograms indicate the absolute values of Firefly/Renilla luciferase activity ratios. The data are the means ± S.E. of three independent experiments performed in triplicate. *P < 0.05, **P < 0.005 versus the respective basal luciferase activity; ΔP < 0.05, ΔΔP < 0.005 versus the respective luciferase activity in response to HGF

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Molecular Cancer

ISSN: 1476-4598