Fig. 3From: Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapyEffects of FGFR1 inhibitors on cell growth. a, Fold change in cell number 48Â h after treatment with IMB-R1. b, Temporal change in MG63 cell number following treatment with IMB-R1 (1:250). c, Cell number following FGF2 treatment (20Â ng/ml for MG63, 5Â ng/ml for MDAMB468 and T47D) for 48Â h. Cells were pre-treatment with IMB-R1 for 1Â h before FGF2 treatment. d, Cell number (MG63) following 48Â h treatment with IMB-R1 or antigen-purified IMB-R1. e, Cell numbers following 48Â h treatment with varying doses of FGFR inhibitors. f, Cell numbers following 48Â h treatment with the FGFR1 antibody (MAB765) at varying doses. Unless otherwise stated, IMB-R1 was applied at a dilution of 1:250. All experiments were performed in triplicateBack to article page