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Fig. 6 | Molecular Cancer

Fig. 6

From: Targeting the heparin-binding domain of fibroblast growth factor receptor 1 as a potential cancer therapy

Fig. 6

The effect of IMB-R1 on gene expression. Cells were treated with IMB-R1 (1:250 dilution) for 48 h and RNA extracted for microarray analysis. a, The heatmaps: Red, up-regulation; Green, down-regulation. b, Top 10 affected cellular functions by IMB-R1 as determined by Ingenuity Pathway Analysis. c, The number of common genes affected across the different cells. d, The antioxidant genes significantly regulated by IMB-R1. e, The proposed signaling mechanisms disrupted by IMB-R1 during FGF2/FGFR1 dependent cell growth and survival in cancer cells

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Molecular Cancer

ISSN: 1476-4598