Skip to main content
Fig. 5 | Molecular Cancer

Fig. 5

From: Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer

Fig. 5

Effects of co-targeting IGF-1R and Src on the growth of xenograft tumors and patient-derived heterotransplants. H460 and H1975 cells (a) or tumors derived from a NSCLC patient (c) were subcutaneously injected into athymic nude mice or NOD/SCID mice. Mice bearing tumors were treated with linsitinib (Linsi), dasatinib (Dasa), or their combination. (a and c) The data are presented as the mean tumor volume ± SD for the indicated times. *P < 0.05, **P < 0.01, and ***P < 0.001. (b) The tumors were subjected to IHC analysis to determine the levels of PCNA, pIGF-1R, pSrc, and cleaved caspase-3 (cl-Caspase3) staining. Representative tumors from each group are shown. (d) Body weight of the treated mice was monitored every 2 days

Back to article page

Molecular Cancer

ISSN: 1476-4598