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Fig. 1 | Molecular Cancer

Fig. 1

From: The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

Fig. 1

CCR6 expression increases throughout cancer development and results in a higher number of mammary tumors. a Top: Representative H&E images of mammary tissue from normal gland and various stages of PyMT-driven tumorigenesis as indicated. Scale bar is 200 μm. Bottom: Proportion of CCR6-positive epithelial cells (CD45-negative) purified from mammary glands at respective stages of tumorigenesis. 18 normal samples (2 glands/sample), 7 hyperplastic samples (2 glands/sample), 6 early carcinomas and 3 late carcinomas were analyzed. b ELISA for CCL20, the ligand for CCR6, in normal (left) and early neoplastic MMTV-PyMT Ccr6 WT (right) mammary glands. n = 4 samples per genotype. c Kaplan-Meier analysis of the palpable tumor onset in MMTV-PyMT Ccr6 −/− mice (n = 14) vs MMTV-PyMT Ccr6 WT mice (n = 11). d Age of tumor onset in MMTV-PyMT Ccr6 −/− mice and MMTV-PyMT Ccr6 WT mice. e Mammary tumor incidence in MMTV-PyMT Ccr6 WT (n = 9) and Ccr6 −/− (n = 14) mice

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Molecular Cancer

ISSN: 1476-4598