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Fig. 3 | Molecular Cancer

Fig. 3

From: The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

Fig. 3

CCR6 promotes mammary gland neoplasia independently of cancer epithelial cells. a Proliferation assay of mammary epithelial cells purified from MMTV-PyMT Ccr6 WT mice at the stage of early neoplasia with and without stimulation by recombinant CCL20 (100 ng/ml). Fetal calf serum (0.5 %) and EGF (20 ng/ml) were used as positive controls. Data are representative of 3 independent experiments, n = 3 mice per experiment. b Analysis of Ki67-positive proliferating cells within MMTV-PyMT Ccr6 WT and Ccr6 −/− mice at the stage of early neoplasia. Shown are representative fields from 2 separate tumors per genotype, displaying equal distribution of cells positive for Ki67

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Molecular Cancer

ISSN: 1476-4598