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Fig. 6 | Molecular Cancer

Fig. 6

From: The chemokine receptor CCR6 facilitates the onset of mammary neoplasia in the MMTV-PyMT mouse model via recruitment of tumor-promoting macrophages

Fig. 6

CCR6-mediated pro-tumorigenic macrophages promote breast cancer in vivo. a Schematic of macrophage reconstitution assay to determine contribution of macrophages to mammary tumorigenesis in the context of CCR6 deletion. TAM = tumor-associated macrophage. b FACS plot showing the sorted macrophage population used for reconstitution. c Tumor-free survival curves over the course of the experiment. d Tumor weight of control tumors generated in Ccr6 WT recipients and in Ccr6 −/− recipients ± TAMs. n = 6-8 tumors per group. e Macrophage numbers in experimental groups at end-point, as assessed by flow cytometry. n = 3-4 samples per group

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Molecular Cancer

ISSN: 1476-4598