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Fig. 5 | Molecular Cancer

Fig. 5

From: Genomic analysis and selective small molecule inhibition identifies BCL-XL as a critical survival factor in a subset of colorectal cancer

Fig. 5

Silencing MCL1 sensitizes colorectal cells to BCL-XL inhibitor while silencing NOXA renders resistance to BCL-XL inhibitor. a MCL1 or control siRNA were transfected into RKO and GEO cells in the presence of A-1155463. Viability was determined after 48 h by microscopy. Western blotting showing the degree of MCL-1 knockdown by MCL1 siRNAs in GEO and RKO cells. b NOXA or control siRNA was transfected into LS1034 cells in the presence or absence of A-1155463. Viability was determined after 48 h. Results were normalized to cells transfected with scrambled siRNA control and presented as mean +/− SD (n = 3). *p < 0.01, **p < 0.005. Western blotting showing the degree of NOXA knockdown by NOXA siRNA pool

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Molecular Cancer

ISSN: 1476-4598