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Fig. 2 | Molecular Cancer

Fig. 2

From: Epiregulin contributes to breast tumorigenesis through regulating matrix metalloproteinase 1 and promoting cell survival

Fig. 2

Decreased expression of EREG leads to reduced acinar growth in vitro. a MCF10DCIS cells were transduced with either non-targeting (NT) or two different EREG shRNA constructs. Expression levels of EREG were determined by qRT-PCR and normalized to levels of CYBP. b Quantification of acinar size. c Quantification of apoptotic structures. d MCF10DCIS cells expressing either NT shRNA or shEREG were plated in Matrigel and allowed to establish for 4 days followed by treatment with 1 μg/ml doxycycline for an additional 4 days. Upper panels show images obtained by light microscopy. Lower panels show apoptotic cells within structures visualized by TUNEL staining. Scale bars represent 200 μm. *p < 0.01, **p < 0.005

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Molecular Cancer

ISSN: 1476-4598