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Fig. 1 | Molecular Cancer

Fig. 1

From: AduPARE1A and gemcitabine combined treatment trigger synergistic antitumor effects in pancreatic cancer through NF-κB mediated uPAR activation

Fig. 1

Evaluation of the cytotoxic effects of the combination AduPARE1A plus gemcitabine in cellular models. a Dose–response curves of gemcitabine, AduPARE1A or combined treatment in BxPC-3 and PANC-1 cell lines. Cells were seeded in triplicate in a 96-well plate (3 × 103 cells/well) and treated with a dose range of gemcitabine (ng/mL) and/or AduPARE1A (vp/mL). Cell viability was measured 3 days later, and is expressed as the percentage of absorbance of treated cells compared with mock-treated cultures. IC50 values for monotherapy or combination therapy for each treatment are represented in bar graphs. b Combination Index values (CI) for the interaction of gemcitabine and AduPARE1A treatments are depicted as a function of inhibitory fractions. Results are expressed as a mean of at least four independent experiments ± SEM

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Molecular Cancer

ISSN: 1476-4598