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Fig. 1 | Molecular Cancer

Fig. 1

From: Downregulation of dystroglycan glycosyltransferases LARGE2 and ISPD associate with increased mortality in clear cell renal cell carcinoma

Fig. 1

Multiple genes in the DG glycosylation pathway are downregulated during tumor progression. Global analysis of the DG glycosyltransferase pathway describes expression, somatic copy number alterations, and mutational frequency. a. Volcano plot demonstrating significance and magnitude change for the analyzed gene set. b. Differences in log-transformed expression of the various glycosyltransferases. Error bars represent ± 1 SD. c. Utilization of the GISTIC copy number alteration analysis tool through the cBioportal shows frequency of heterozygosity in the analyzed gene set. d. Mutational analysis from the cBioportal shows demonstrates the low frequency of mutation within the pathway. Each vertical grouping represents one patient. Mutations are marked in green. Total number of tumors analyzed is 424

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