Fig. 2

mRNA expression of multiple genes in the DG glycosylation pathway show a significant association with both disease grade and stage. Odds ratios were calculated for the DG glycosyltransferase pathway. a–b. Stage and grade analysis, adjusted for sex and age, plotted such that a ten-fold downregulation of the indicated genes corresponds to the given increase in odds (right of the axis). 95 % confidence intervals are shown by the horizontal bar. P values are listed to the right of the respective genes. Those genes to the right of the y-axis were inversely associated with increasing nuclear grade or tumor stage. For example, a ten-fold down–regulation of ISPD was associated with a 1.7-fold increase in the odds of a higher nuclear grade and stage for the tumor