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Fig. 1 | Molecular Cancer

Fig. 1

From: Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma

Fig. 1

Bevacizumab promotes venous thrombosis. a. IVC stenosis was induced in tumor-bearing mice (n = 6/group). Three hours after ligation, mice were euthanized and the weight of the thrombus was determined. Representative whole thrombi and cross-sections of thrombi retrieved from mice treated with bevacizumab (Beva) or vehicle control are shown. *P < 0.05 vs. vehicle control. b. Saphenous vein thrombosis was induced using 10 % FeCl3 in control (n = 6) and A549 tumor-bearing mice (n = 6). Occlusion times were measured and are shown as the mean ± SEM. *P < 0.05 vs. the vehicle group. c. Tumors were excised and lysates were prepared and subjected to Western blotting to detect VEGF-A, PAI-1, and β-actin. Representative blots and densitometric analyses of 3 independent experiments are shown. *P < 0.05 vs. control. d. Plasma PAI-1 antigen was measured (n = 6/group); *P < 0.05 vs. the vehicle group. Beva: bevacizumab

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