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Fig. 3 | Molecular Cancer

Fig. 3

From: Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma

Fig. 3

Pharmacological inhibition of PAI-1 blocks the prothrombotic effect of bevacizumab. a. IVC stenosis was induced in tumor-bearing mice. The mean weight of the thrombus was determined. *P < 0.05 vs. the vehicle group; **P < 0.05 vs. the beva group; #P > 0.05 vs. beva + PAI-039 group (n = 6/group). b. Mean occlusion times were measured in a saphenous vein thrombosis model and are shown as the mean ± SEM. *P < 0.01 vs. the vehicle group; **P < 0.05 vs. the beva group; #P > 0.05 vs. beva + PAI-039 group (n = 6/group). Beva: bevacizumab

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Molecular Cancer

ISSN: 1476-4598