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Fig. 3 | Molecular Cancer

Fig. 3

From: Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

Fig. 3

PI3K and ERK inhibitors abrogates EMT-mediated PD-L1 upregulation a EMT-mediated PD-L1 upregulation in MCF-12A cells in the presence or absence of major EMT pathway inhibitors, calculated as a percentage of the level of PD-L1 in untreated cells as per the equation \( \%\ \mathrm{upregulation}=\frac{\mathrm{PDL}1\ \mathrm{expression}\ \mathrm{after}\ \mathrm{T}\mathrm{G}\mathrm{F}1\ \mathrm{treatment}-\mathrm{P}\mathrm{D}\mathrm{L}1\ \mathrm{before}\ \mathrm{T}\mathrm{G}\mathrm{F}1\ \mathrm{treatment}}{\mathrm{PDL}1\ \mathrm{before}\ \mathrm{T}\mathrm{G}\mathrm{F}1\ \mathrm{treatment}\ \mathrm{and}\ \mathrm{without}\ \mathrm{any}\ \mathrm{blocker}} \times 100 \) b Representative flow cytometry histogram of PD-L1 before and after TGF-β1 treatment in the presence or absence of EMT inhibitors

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