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Fig. 4 | Molecular Cancer

Fig. 4

From: Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: Significance in claudin-low breast cancer cells

Fig. 4

Correlation of PD-L1 expression, EMT and claudin-low subtype of breast cancer using TCGA gene expression dataset. Gene expression dataset from the TCGA breast cancer samples (total of 530 patients) showing the correlation of PD-L1 expression with EMT score and claudin-low breast cancer A&C). Heat map showing mRNA expression level of mesenchymal and Epithelial genes in addition to top 100 claudin-low gene expression signature (up- or down-regulated in CL). The samples in the data are arranged according to their EMT score (a) or according to their claudin-low score (c) and compared with PD-L1 expression, as indicated with the arrow at the top. B&D) Scatter plot of PD-L1 mRNA expression level correlates significantly that of with ZEB2 (b) or claudin-low score (d) in TCGA breast cancer samples (p < 0.0001)

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