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Fig. 6 | Molecular Cancer

Fig. 6

From: MicroRNA-1908 functions as a glioblastoma oncogene by suppressing PTEN tumor suppressor pathway

Fig. 6

PTEN is a direct target of miR-1908. a Correlation of miR-1908 overexpression with PTEN downregulation in indicated glioblastoma tissues. b PTEN expression in miR-1908 overexpressing cells in western blot. c PTEN expression in miR-1908 silencing cells in western blot. d ICH for PTEN in miR-1908 overexpressing tumors and control. e Wild-type miR-1908 target sequences of PTEN 3’-UTR and mutant-type miR-1908 target sequences of PTEN 3’-UTR. f and g Relative luciferase activity of PTEN in cells after co-transfection with wild type (Wt) or mutant (Mt) PTEN 3’-UTR reporter genes and miR-1908 mimics, anti-miR-1908 mimics or control. **P < 0.01 based on the Student t test. Error bars, SD

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