Fig. 5
From: Retinoic acid-induced CHD5 upregulation and neuronal differentiation of neuroblastoma
Effect of the TRK inhibitor CEP-701 on RA induced CHD5 expression. (a) CHD5 expression in SY-5Y-TrkA cells with or without RA and in the presence or absence of CEP-701. The values for CEP-701 inhibition were calculated relative to the levels of CHD5 expression upon 13cRA treatment. The graph shows the results of three independent experiments. Statistical analysis was performed using one-way ANOVA using Prism followed by Tukey’s post-test and P-values were reported as shown. (b) Protein expression of CHD5 and HDAC2. (c) Densitometric analysis of CHD5 protein expression in SY5Y-TrkA cells. The number of pixels from each band obtained from a representative Western blot were measured, and a bar graph was created using Prism to indicate the difference in CHD5 expression between control, 13cRA and CEP-701 treatments