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Fig. 6 | Molecular Cancer

Fig. 6

From: Upregulation of microRNA-122 by farnesoid X receptor suppresses the growth of hepatocellular carcinoma cells

Fig. 6

FXR agonist represses the growth of HCC xenografts and upregulates miR-122 expression in vivo. a A total of 5 × 106 Hep3B cells were injected into the right axillae of each nude mouse. After 11 days, the mice were randomly assigned to different groups (n = 5 per group), and treated daily with vehicle or GW4064 at 40 mg/kg by intraperitoneal injection for 8 d. The xenograft tumor volume was monitored every other day. b HCC xenografts were harvested for size comparison. c The expression of Ki67 (a marker of cell proliferation) in HCC xenografts was examined by immunohistochemical staining. d and e The expression of miR-122, IGF-1R and cyclin G1 in HCC xenografts was separately detected by qRT-PCR (d) and Western blotting (e). *P < 0.05, **P < 0.01 vs vehicle

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