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Fig. 1 | Molecular Cancer

Fig. 1

From: Carbon ion beam combined with cisplatin effectively disrupts triple negative breast cancer stem-like cells in vitro

Fig. 1

a. Colony, spheroid formation and tumorigenicity of cancer stem-like cells (CSCs) (CD44+/CD24-) and non-CSCs (CD44-/CD24-) delivered from MDA-MB-231 cells. The cells were cultured for 1–2 weeks or injected into NOD-SCID mouse right and left thighs for 12–16 weeks for colony, spheroid and tumor formation ability analyses. b. Spheroid formation and tumorigenicity of cancer stem-like cells (CSCs) (ESA+/CD24-) and non-CSCs (ESA-/CD24-) delivered from MDA-MB-453 cells. The cells were cultured for 1–2 weeks or injected to NOD-SCID mouse right and left thighs for 12–16 weeks for colony, spheroid and tumor formation ability analyses. CSCs formed tumor HE is displayed. Representative photos of CSCs are also displayed. *, p < 0.01, compared to colony or sphere formed from non-CSCs. All experiments were performed in triplicate (n = 3)

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Molecular Cancer

ISSN: 1476-4598