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Table 1 Multivariate analysis of several variables for OS and RFS

From: Aldolase B inhibits metastasis through Ten–Eleven Translocation 1 and serves as a prognostic biomarker in hepatocellular carcinoma

Variablea Recurrence-Free Survival Overall Survival
Hazardratio(95 % CI) P-value Hazardratio(95 % CI) P-value
HBs antigen, positive 2.046(1.221–3.430) 0.007* 2.173(1.171–4.031) 0.014*
HBe antigen, positive 1.526(1.093–2.131) 0.013* 1.517(1.050–2.193) 0.027*
Liver cirrhosis, Present 1.485(1.070–2.061) 0.018* -- --
Tumor size(cm),>5 1.537(1.143–2.066) 0.004* 1.713(1.225–2.395) 0.002*
No. tumor, Multiple -- -- -- N.S.
Differentiation, III + IV -- N.S. -- N.S.
Micro-vascular invasion, Present -- N.S. -- N.S.
Macro-vascular invasion, Present -- N.S. -- N.S.
Encapsulation, Absent 1.527(1.113–2.097) 0.009* 1.634(1.135–2.351) 0.008*
TNM stage, II + III -- N.S. -- N.S.
BCLC stage, B + C 1.775(1.288–2.444) 0.001* 1.917(1.351–2.721) 0.000*
ALDOB expression, Low 1.351(1.006–1.815) 0.045* 1.437(1.030–2.003) 0.033*
  1. N.S., not significant
  2. *P < 0.05 by Cox proportional hazards regression model
  3. aVariables were adopted for their prognostic significance by univariate analysis