Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer

Table 1 Association between SNPs in TCA cycle related genes and CRC outcomes in primary cohort

Gene	SNP	Call rate (%)	Function	OS			RFS
Gene	SNP	Call rate (%)	Function	Best fitting model	HR (95 % CI)^a	P value	Best fitting model	HR (95 % CI)^a	P value
SDHA	rs13173911	99.0	TFBS	Additive	0.86(0.52-1.44)	0.573	Additive	0.88(0.55-1.40)	0.589
	rs2864963	98.4	TFBS	Dominant	0.92(0.69-1.21)	0.533	Dominant	0.92(0.71-1.19)	0.522
SDHB	rs3754509	98.0	TFBS	Recessive	0.96(0.66-1.40)	0.823	Recessive	0.88(0.62-1.27)	0.504
SDHC	rs12064957	98.9	TFBS	Additive	1.36(1.06-1.74)	0.015	Additive	1.21(0.95-1.54)	0.117
	rs3935401	98.7	miRNA	Recessive	1.25(0.68-2.31)	0.476	Dominant	0.91(0.70-1.19)	0.484
	rs4131826	96.1	TFBS	Additive	0.61(0.47-0.79)	1.8x10 ^-4	Additive	0.73(0.58-0.91)	0.005
SDHD	rs10789859	98.3	TFBS	Additive	1.19(0.97-1.45)	0.088	Additive	1.29(1.08-1.55)	0.006
	rs544184	96.8	TFBS	Recessive	1.52(1.05-2.19)	0.026	Additive	1.31(1.08-1.58)	0.005
	rs7121782	98.3	TFBS	Recessive	1.49(1.04-2.14)	0.031	Additive	1.29(1.07-1.55)	0.008
IDH1	rs12478635	97.4	TFBS	Additive	1.04(0.85-1.28)	0.682	Dominant	1.02(0.76-1.38)	0.875
IDH2	rs11540478	99.0	Splicing	Additive	0.91(0.69-1.19)	0.490	Additive	0.96(0.75-1.23)	0.731
	rs11632348	98.3	TFBS	Recessive	0.67(0.36-1.24)	0.203	Recessive	0.69(0.39-1.24)	0.218
	rs4283211	98.6	TFBS	Dominant	0.88(0.66-1.17)	0.387	Additive	0.94(0.75-1.18)	0.593
FH	rs12071124	97.4	TFBS	Additive	0.83(0.67-1.03)	0.086	Recessive	0.62(0.43-0.90)	0.013
	rs1414493	97.8	TFBS	Recessive	1.08(0.73-1.58)	0.709	Dominant	1.14(0.86-1.53)	0.359
	rs7530270	98.7	TFBS	Recessive	0.85(0.60-1.21)	0.361	Recessive	0.76(0.54-1.05)	0.100

Abbreviations: CI confidence interval, HR hazard ratio, OS overall survival, RFS recurrence free survival. Significant p values were in bold
^aAdjusted for gender, age, hospital site, tumor position, clinical stage, differentiation and treatment after surgery

ISSN: 1476-4598