Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer

Table 2 Association between significant SNPs and 256 CRC patients’ outcome in validation cohort

Gene	SNP	Call rate (%)	Function	OS			RFS
Gene	SNP	Call rate (%)	Function	Best Fitting Model	HR^a (95 % CI)	P-value	Best Fitting Model	HR^a (95 % CI)	P-value
SDHC	rs12064957	98.8	TFBS	Additive	1.16(0.79-1.70)	0.450	Additive	1.14(0.84-1.54)	0.406
	rs4131826	96.1	TFBS	Additive	0.66(0.46-0.94)	0.022	Additive	0.73(0.55-0.97)	0.027
SDHD	rs544184	97.3	TFBS	Recessive	2.30(1.40-3.78)	0.001	Recessive	2.02(1.33-3.07)	0.001
FH	rs12071124	96.5	TFBS	Additive	0.90(0.67-1.22)	0.511	Additive	0.77(0.60-0.98)	0.033

Abbreviations: CI confidence interval, HR hazard ratio, OS overall survival, RFS recurrence free survival. Significant P values were in bold
^aAdjusted by gender, age,tumor position, clinical stage, differentiation and treatment after surgery where appropriate

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