Genetic variations in genes of metabolic enzymes predict postoperational prognosis of patients with colorectal cancer

Table 3 Cumulative effect of unfavorable genotypes on CRC outcomes

Group(number of unfavorable genotypes^a)	Death/Total	HR (95 % CI)^b	P value	Recurrence/Total	HR^b (95 % CI)	P value
Group 1 (0-1)	20/138	Ref.		29/138	Ref.
Group 2 (2)	78/246	1.93(1.18-3.18)	0.009	94/246	1.81(1.19-2.76)	0.006
Group 3 (3)	59/190	2.14(1.28-3.58)	0.004	68/190	1.89(1.21-2.93)	0.005
Group 3 (4)	31/69	3.17(1.79-5.61)	7.30 × 10 ^-5	31/69	2.45(1.47-4.09)	0.001
P for trend			1.12 × 10 ^-4			0.001

Abbreviations: CI confidence interval, HR hazard ratio, Ref. reference
^aUnfavorable genotypes: SDHC rs12064957 (WV + VV) and rs4131826 WW, SDHD rs544184 (WV + VV), and FH rs12071124 (WW + WV)
^bAdjusted for gender, age, hospital site, tumor position, clinical stage, differentiation and treatment after surgery
Significant P values (<0.05) were bolded

ISSN: 1476-4598