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Table 2 Outcomes of assessable patients with pancreatic cancer according to protein expression

From: Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

Variable

Overall survival

Disease-free survival

 

HR

95 % CI

P

HR

95 % CI

P

LC3

  Low (n = 50)

1

0.087–0.589

0.200

1

0.251–1.387

0.226

  High (n = 43)

0.227

  

0.590

  

ALDH1

  Low (n = 51)

1

0.516–3.684

0.522

1

0.315–1.481

0.335

  High (n = 42)

1.378

  

0.684

  

LC3/ALDH1

  Low (n = 54)

1

1.622–13.739

0.004

1

2.535–17.170

0.000

  High (n = 39)

4.721

  

6.597

  

OPN

  Low (n = 58)

1

0.233–2.430

0.634

1

0.442–4.234

0.587

  High (n = 35)

0.752

  

1.368

  

OPN/LC3/ALDH1

  Low (n = 42)

1

Reference

 

1

Reference

 

  Moderate (n = 28)

1.770

0.846–3.704

0.130

1.351

0.773–2.362

0.291

  High (n = 23)

2.385

1.129–5.038

0.023

2.245

1.183–4.259

0.013

OPN/CD44/CD133

  Low (n = 39)

1

Reference

 

1

Reference

 

  Moderate (n = 42)

1.929

0.897–4.146

0.093

1.639

0.889–3.021

0.113

  High (n = 12)

4.527

1.403–14.604

0.011

4.140

1.672–10.254

0.002

  1. The bold value indicates P < 0.05