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Fig. 9 | Molecular Cancer

Fig. 9

From: Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells

Fig. 9

Butyrate decreases c-Myc and miR-92a levels and increases p57 expression in colon cancer cells. a In colon cancer cells, high levels of c-Myc up-regulate miR-17-92a transcription. Over-expressed miR-92a inhibits p57 mRNA translation, thus attenuating the cellular actions of p57 protein. b Treatment with butyrate up-regulates both p57 transcription and p57 mRNA translation. The effect of butyrate on p57 mRNA translation is mediated via reduced c-Myc protein expression, which decreases miR-17-92a cluster transcription and miR-92a levels. Collectively, the interactions between butyrate, c-Myc, miR-92a and p57 mediate butyrate’s anti-proliferative and pro-apoptotic effects, both relevant to colon neoplasia

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