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Table 2 Cox analysis of the prognostic variables on the overall survival in patients ( Whole blood)

From: Nuclear-enriched abundant transcript 1 as a diagnostic and prognostic biomarker in colorectal cancer

Prognosis variables Overall survival
P value HR (95 % CI)
Univariate analysis   
 NEAT1_v1, Low/High 0.004* 0.415 (0.227–0.758)
 NEAT1_v2, Low/High 0.285 1.421 (0.746–2.708)
 NEAT1_v2, High Alonea 0.006* 0.426 (0.231–0.784)
 Gender, Male/Female 0.399 1.290 (0.714–2.330)
 Age, <56/≥56 yearsb 0.967 0.988 (0.544–1.793)
 Tumor (T) stage, T1–2/T3–4 0.124 0.399 (0.124–1.288)
 Nodal (N) status, N0/N1 <0.001* 0.120 (0.056–0.257)
 N0/N2 <0.001* 0.297 (0.143–0.617)
 Distant metastasis (M), M0/M1 <0.001* 0.102 (0.055–0.188)
 Lymphatic/vascular invasion, No/Yes <0.001* 0.243 (0.135–0.438)
 Perineural invasion, No/Yes 0.001* 0.342 (0.179–0.653)
 Extranodal tumor deposit, No/Yes 0.005* 0.389 (0.201–0.753)
 AJCC Stagec, I–II/III–IV <0.001* 0.205 (0.066–0.426)
 Differentiation, G1–G2/G3–G4 0.058 0.543 (0.289–1.022)
 Pathology, Adenocarcinoma/Mucinous or signet-ring carcinoma 0.712 0.859 (0.384–1.923)
 Size, <5/≥5b 0.598 1.187 (0.627–2.247)
Multivariate analysis   
 NEAT1_v1, Low/High 0.068  
 NEAT1_v2, High Alonea 0.038* 0.519 (0.280–0.965)
 Nodal (N) status, N0/N1 <0.001* 0.199 (0.088–0.452)
 N0/N2 0.017* 0.402 (0.189–0.851)
 Distant metastasis (M), M0/M1 <0.001* 0.193 (0.099–0.374)
 Lymphatic/vascular invasion, No/Yes 0.996  
 Perineural invasion, No/Yes 0.366  
 Extranodal tumor deposit, No/Yes 0.645  
 AJCC Stagec, I–II/III–IV 0.498  
  1. *A two-tailed p value ≤0.05 was considered statistically significant
  2. aHigh expression of NEAT1_v2 with low expression of NEAT1_v1
  3. bThe mean age and tumor size, respectively
  4. cAbbreviations: AJCC, American Joint Committee on Cancer (AJCC)