Fig. 3
H19 in metastasis. H19 plays a role in both epithelial to mesenchymal transition in the primary tumor and colonization and re-differentiation/accommodation to niche in the secondary site. As delineated above, various contradictory pathways are controlled by H19 in the two scenarios. H19 is consolidated into the process active at that time, which is a function of the micro-environmental factors, and may find other partners in each of the scenarios (miR-200 and let-7 in EMT and putative alternative partners such as histone acetylases in MET)