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Table 1 Molecular signatures and defense profiles of glioblastoma stem cells (GSC) resistant to 500μM TMZa

From: Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide

Gene Fold change P value Functional involvement
MB2: metastasis related protein 9.48 0.037251 human lung cancer cell metastasis-related gene
GRP: gastrin-releasing peptide 3.03 0.012739 activates stress responses; blocks ER stress-mediated apoptosis; angiogenesis
NNMT: nicotinamide N-methyltransferase 3.02 0.016864 biotransformation of xenobiotics, detoxification, drug resistance, DNA repair
RUNDC3B: RUN domain containing 3B 2.63 0.022848 tumor invasion, tumorigenic capacity, malignant transformation
PPP1R14C: protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.45 0.038521 tumor suppressor, upregulates early growth response 1 and PTEN gene expression
FAM46A: family with sequence similarity 46, member A 2.35 0.026347 retinal signaling pathways
SYTL2: synaptotagmin-like 2 2.07 0.006201 vesicle trafficking
EGR1: early growth response 1 2.00 0.012287 impaired insulin/Akt signaling, reduced glucose uptake, autophagy, Sirt1 expression
ZNF652: zinc finger protein 652 1.88 0.024023 a transcriptional repressor, tumor suppressor
MAP4: microtubule-associated protein 4 1.85 0.007016 stabilizes mitochondria, microtubule network, and cell viability
APOLD1: apolipoprotein L domain containing 1 1.85 0.006038 angiogenesis, blood-brain permeability
ANKRD10: ankyrin repeat domain 10 1.85 0.011112 unknown
C5orf32: chromosome 5 open reading frame 32 1.79 0.005850 stress tolerance
SLFN5: Schlafen family member 5 1.74 0.025479 growth-inhibitory responses, tumor suppressor
MCAM: melanoma cell adhesion molecule 1.73 0.004659 cell adhesion, EMT
MST150: MSTP150 1.72 0.010533 induced by nerve growth factor
NR2F1: Nuclear receptor subfamily 2, group F, member 1 1.68 0.003457 tumor dormancy, cell motility, and invasiveness
PRRG4: Proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) 1.65 0.009662 downregulates ERK 1/2 signaling, cell cycle control
RRAS: related RAS viral (r-ras) oncogene homolog 1.62 0.022906 maintains endothelial barrier function, cell migration
CDKN1A: cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.60 0.018892 cell cycle regulator, cellular quiescence, tumor suppressor
FAM114A1: family with sequence similarity 114, member A1 1.59 0.026679 neuronal cell development
INPP4B: inositol polyphosphate-4-phosphatase, type II, 105kDa 1.57 0.004296 phospholipid metabolism, tumor suppressor, inhibits PI3K/Akt signaling
FN1: fibronectin 1 1.56 0.037537 EMT, cell adhesion and migration, angiogenesis
C6orf57: chromosome 6 open reading frame 57 1.54 0.036557 mitochondrial function
VDAC1: voltage-dependent anion channel 1 1.52 0.005105 respiratory electron transport
PSAT1: phosphoserine aminotransferase 1 1.52 0.029482 serine synthesis pathway; amino acid/phospholipid/nucleotide synthesis
ZEB1: zinc finger E-box binding homeobox 1 1.51 0.038506 transcriptional repression of interleukin 2
MALAT1: metastasis associated lung adenocarcinoma transcript 1 1.51 0.021777 EMT, migration, invasion, metastasis, angiogenesis
FAT3: FAT tumor suppressor homolog 3 (Drosophila) 1.51 0.014515 controls neuronal morphology
MFSD2: major facilitator superfamily domain containing 2 −1.53 0.006302 plays a role during fasting and adaptive thermogenesis
NUP160: nucleoporin 160kDa NUP98: nucleoporin 98kDa −1.55 0.049580 promotes mitotic spindle assembly, contributes to proper kinetochore functions
NUP98: nucleoporin 98kDa −1.59 0.032310 a nuclear pore complex component; a transcription factor
DPP6: dipeptidyl-peptidase 6 −1.06 0.013619 interaction with extracellular matrix
FJX1: four jointed box 1 (Drosophila) −1.62 0.004725 growth and differentiation
NRP2: neuropilin 2 −1.63 0.041599 cardiovascular development, axon guidance, and tumorigenesis
BMP7: bone morphogenetic protein 7 (osteogenic protein 1) −1.98 0.002699 cartilage and bone formation; differentiation and proliferation
  1. ER endoplasmic reticulum; EMT epithelial-to-mesenchymal transition
  2. aProbe set signals on the expression array that were ≥ 1.5-fold different in GSC-500 μM TMZ (n=3 patients, 6 samples) when compared to GSC-parental (n = 3 patients, duplicate samples) by a pairwise t-test (P < 0.05), were selected. Samples were permutated 100 times by dChip, and 36 annotated genes with median FDR = 4 % were obtained