Gene | Fold change | P value | Functional involvement |
---|---|---|---|
MB2: metastasis related protein | 9.48 | 0.037251 | human lung cancer cell metastasis-related gene |
GRP: gastrin-releasing peptide | 3.03 | 0.012739 | activates stress responses; blocks ER stress-mediated apoptosis; angiogenesis |
NNMT: nicotinamide N-methyltransferase | 3.02 | 0.016864 | biotransformation of xenobiotics, detoxification, drug resistance, DNA repair |
RUNDC3B: RUN domain containing 3B | 2.63 | 0.022848 | tumor invasion, tumorigenic capacity, malignant transformation |
PPP1R14C: protein phosphatase 1, regulatory (inhibitor) subunit 14C | 2.45 | 0.038521 | tumor suppressor, upregulates early growth response 1 and PTEN gene expression |
FAM46A: family with sequence similarity 46, member A | 2.35 | 0.026347 | retinal signaling pathways |
SYTL2: synaptotagmin-like 2 | 2.07 | 0.006201 | vesicle trafficking |
EGR1: early growth response 1 | 2.00 | 0.012287 | impaired insulin/Akt signaling, reduced glucose uptake, autophagy, Sirt1 expression |
ZNF652: zinc finger protein 652 | 1.88 | 0.024023 | a transcriptional repressor, tumor suppressor |
MAP4: microtubule-associated protein 4 | 1.85 | 0.007016 | stabilizes mitochondria, microtubule network, and cell viability |
APOLD1: apolipoprotein L domain containing 1 | 1.85 | 0.006038 | angiogenesis, blood-brain permeability |
ANKRD10: ankyrin repeat domain 10 | 1.85 | 0.011112 | unknown |
C5orf32: chromosome 5 open reading frame 32 | 1.79 | 0.005850 | stress tolerance |
SLFN5: Schlafen family member 5 | 1.74 | 0.025479 | growth-inhibitory responses, tumor suppressor |
MCAM: melanoma cell adhesion molecule | 1.73 | 0.004659 | cell adhesion, EMT |
MST150: MSTP150 | 1.72 | 0.010533 | induced by nerve growth factor |
NR2F1: Nuclear receptor subfamily 2, group F, member 1 | 1.68 | 0.003457 | tumor dormancy, cell motility, and invasiveness |
PRRG4: Proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) | 1.65 | 0.009662 | downregulates ERK 1/2 signaling, cell cycle control |
RRAS: related RAS viral (r-ras) oncogene homolog | 1.62 | 0.022906 | maintains endothelial barrier function, cell migration |
CDKN1A: cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.60 | 0.018892 | cell cycle regulator, cellular quiescence, tumor suppressor |
FAM114A1: family with sequence similarity 114, member A1 | 1.59 | 0.026679 | neuronal cell development |
INPP4B: inositol polyphosphate-4-phosphatase, type II, 105kDa | 1.57 | 0.004296 | phospholipid metabolism, tumor suppressor, inhibits PI3K/Akt signaling |
FN1: fibronectin 1 | 1.56 | 0.037537 | EMT, cell adhesion and migration, angiogenesis |
C6orf57: chromosome 6 open reading frame 57 | 1.54 | 0.036557 | mitochondrial function |
VDAC1: voltage-dependent anion channel 1 | 1.52 | 0.005105 | respiratory electron transport |
PSAT1: phosphoserine aminotransferase 1 | 1.52 | 0.029482 | serine synthesis pathway; amino acid/phospholipid/nucleotide synthesis |
ZEB1: zinc finger E-box binding homeobox 1 | 1.51 | 0.038506 | transcriptional repression of interleukin 2 |
MALAT1: metastasis associated lung adenocarcinoma transcript 1 | 1.51 | 0.021777 | EMT, migration, invasion, metastasis, angiogenesis |
FAT3: FAT tumor suppressor homolog 3 (Drosophila) | 1.51 | 0.014515 | controls neuronal morphology |
MFSD2: major facilitator superfamily domain containing 2 | −1.53 | 0.006302 | plays a role during fasting and adaptive thermogenesis |
NUP160: nucleoporin 160kDa NUP98: nucleoporin 98kDa | −1.55 | 0.049580 | promotes mitotic spindle assembly, contributes to proper kinetochore functions |
NUP98: nucleoporin 98kDa | −1.59 | 0.032310 | a nuclear pore complex component; a transcription factor |
DPP6: dipeptidyl-peptidase 6 | −1.06 | 0.013619 | interaction with extracellular matrix |
FJX1: four jointed box 1 (Drosophila) | −1.62 | 0.004725 | growth and differentiation |
NRP2: neuropilin 2 | −1.63 | 0.041599 | cardiovascular development, axon guidance, and tumorigenesis |
BMP7: bone morphogenetic protein 7 (osteogenic protein 1) | −1.98 | 0.002699 | cartilage and bone formation; differentiation and proliferation |