Gene | Fold change | P value | Functional involvement |
---|---|---|---|
I. Upregulated genes | Â | Â | Â |
RASAL2: RAS protein activator like 2 | 3.37 | 0.019083 | tumor and metastasis suppressor |
ATXN1: ataxin 1 | 2.59 | 0.013118 | chromatin-binding factor that repress Notch signaling, cell differentiation |
CD44: CD44 molecule (Indian blood group) | 2.59 | 0.023871 | a receptor for hyaluronic acid; modulates Smad1 activation in the BMP7 signaling |
ZNF638: protein 638 | 2.33 | 0.030429 | adipocyte differentiation |
CDC14B: CDC14 cell division cycle 14 homolog B (S. cerevisiae) | 2.09 | 0.027588 | cell cycle control |
TGFBR1: Transforming growth factor, beta receptor I | 1.99 | 0.015786 | cell cycle arrest in epithelial cells; growth inhibition, cell apoptosis |
PIK3C2A: Phosphoinositide-3-kinase, class 2, alpha polypeptide | 1.63 | 0.037372 | functions in insulin signaling, premature senescence and oxidative apoptosis |
AKAP10: A kinase (PRKA) anchor protein 10 | 1.59 | 0.024294 | control of cell proliferation |
DLC1: deleted in liver cancer 1 | 1.58 | 0.041191 | metastasis suppressor gene, EMT arrest |
BRPF3: bromodomain and PHD finger containing, 3 | 1.44 | 0.035113 | promotes formation of acetyltransferase complexes, stimulates transcription |
SLC20A1: Solute carrier family 20 (phosphate transporter), member 1 | 1.40 | 0.042665 | cellular metabolism, signal transduction, and nucleic acid and lipid synthesis |
RASEF: RAS and EF-hand domain containing | 1.39 | 0.045602 | tumor suppressor, induction of apoptosis, inhibition of proliferation |
MLL: myeloid/lymphoid or mixed-lineage leukemia | 1.38 | 0.024547 | regulates neural progenitor proliferation and neuronal and glial differentiation |
CDK6: cyclin-dependent kinase 6 | 1.37 | 0.047985 | augments accumulation of p53, decreases tumor growth when overexpression |
IGF1R: insulin-like growth factor 1 receptor | 1.34 | 0.045232 | stimulates stem cell differentiation via AKT activation; premature senescence |
POU2F1: POU class 2 homeobox 1 | 1.34 | 0.032549 | anti-inflammation/immune response, cell apoptosis, regulation of NF-kappaB |
IL6ST: interleukin 6 signal transducer (gp130, oncostatin M receptor) | 1.29 | 0.022673 | stimulates osteoblast differentiation, maintains bone formation |
ZNF395: zinc finger protein 395 | 1.29 | 0.030385 | suppresses cell migration and invasion |
ERN2: endoplasmic reticulum to nucleus signaling 2 | 1.28 | 0.037335 | activation of the unfolded protein response |
LGR5: leucine-rich repeat-containing G protein-coupled receptor 5 | 1.27 | 0.030355 | universal epithelial stem cell marker |
IRAK1BP1: interleukin-1 receptor-associated kinase 1 binding protein 1 | 1.27 | 0.024291 | downregulation of inflammatory cytokines, anti-inflammation, growth inhibition |
ARIH2: Ariadne homolog 2 (Drosophila) | 1.26 | 0.032696 | inhibits cell proliferation |
II. Downregulated genes | Â | Â | Â |
NOTCH3: Notch homolog 3 (Drosophila) | −1.25 | 0.037102 | EMT, maintenance of NSC in an undifferentiated quiescent state, angiogenesis |
ASXL1: additional sex combs like 1 (Drosophila) | −1.25 | 0.016868 | suppresses adipogenesis, transcriptional repression |
SEMA6A: sema, transmembrane, and cytoplasmic domains, 6A | −1.25 | 0.041608 | vascular development; tumor angiogenesis; neuronal development |
QPRT: quinolinate phosphoribosyltransferase | −1.25 | 0.027582 | resistance to oxidative stress; suppression of spontaneous cell death |
GPRC5B: G protein-coupled receptor, family C, group 5, member B | −1.26 | 0.029052 | insulin resistance; inflammatory signaling; promotes ERK1/2 activation |
TRO: trophinin | −1.26 | 0.033855 | promotes EMT, invasive and metastatic phenotype; tumor formation |
MFI2: antigen p97 identified by mAb 133.2 and 96.5 | −1.26 | 0.034824 | cell proliferation and tumorigenesis |
METTL3: methyltransferase like 3 | −1.28 | 0.046969 | plays a role in the efficiency of mRNA splicing and processing |
MTMR11: myotubularin related protein 11 | −1.35 | 0.017165 | unknown; cisplatin resistance-associated protein |
COL16A1: collagen, type XVI, alpha 1 | −1.37 | 0.020495 | stimulates tumor proliferation and invasion |
SCARA5: Scavenger receptor class A, member 5 (putative) | −1.40 | 0.024406 | innate immune response; inflammatory response |
CLEC7A: C-type lectin domain family 7, member A | −1.40 | 0.009915 | innate immune response; inflammatory response; migration and proliferation |