Fig. 2
Structure of RNA helicase DDX3. a. Schematic representation of DDX3 (human) and conserved motifs. In grey the two RecA-like domains. The motifs include Q (182F--200YTRPTPVQ), I (226TGSGKT), Ia (274PTRELA), Ib (302GG), Ic (323TPGR), II (347DEAD), III (382SAT), IV (445LVFVET), Iva (477QRDR--487F), V (494ILVAT), Va (502ARGLD), VI (527HRIGRTGR). Conserved amino acid sequences are indicated in parenthesis. Boxes represent the conserved motifs involved in ATP binding (red), RNA binding (green) and linking (blue). b. Crystallography structure of DDX3 (V168-G582) (PDB: 2I4I) with AMP as the substrate (12 conserved motifs are indicated with colors)