Fig. 3
DDX3 interactions with AMP. a. Hydrogen interactions between AMP and amino acid residues of DDX3 ATP binding pocket: the C6 amino group of AMP as a hydrogen donor (HD) and the backbone carbonyl oxygen of Arg202 as a hydrogen acceptor (HA); the 2’-OH group as well as N9 of AMP (both act as HA) and the phenolic oxygen of Tyr200 (HD); N7 of AMP (HA) and the side chain NH2 group of Gln207 (HD); two phosphate oxygens of AMP (HA) and the backbone NH groups of Gly229 and Thr 231 (HD). b. π-π interaction between the aromatic ring of AMP and the phenol side chain of Tyr200