Fig. 3
From: PKM2 regulates neural invasion of and predicts poor prognosis for human hilar cholangiocarcinoma
Association between PKM2 expression and PNI of HC. a, HC patients with PNI had a shorter median time to recurrence than did those without PNI (15 months versus 27 months). Cum, cumulative. b, the PKM2 staining score was higher for tumors with PNI than for tumors without PNI (P = 0.0369). c, HC cells surrounding nerve fibers (S100) exhibited strong staining for PKM2. Original magnification, ×400. D, HC cells entering the perineurium and spreading via local infiltration and metastasis all exhibited intense cytoplasmic staining for PKM2. Original magnification, ×200