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Fig. 1 | Molecular Cancer

Fig. 1

From: RETRACTED ARTICLE: MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α

Fig. 1

MiR-362-5p was up-regulated in leukaemia cell lines and most of the fresh specimens from CML patients; however, this up-regulation could be inhibited, if the CML were in complete hematologic response induced by imatinib. MiR-362-5p was detected by qRT-PCR in the following samples: (a) 4 leukemia cell lines, CD34+ cells and 293Tcells. b 40 CML specimens and 26 normal individual. c Samples from 8 CML patients prior to treatment (at diagnosis time) and after complete hematologic response. d K562 cell line treated with1 μM imatinib. U6 small nuclear RNA gene (U6snRNA) was used as an internal control. Data are shown as mean ± SD. t test,*P < 0.05, ** P <0.01 compare with CD34+ (a), normal (b), untreated (c and d)

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Molecular Cancer

ISSN: 1476-4598