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Fig. 4 | Molecular Cancer

Fig. 4

From: Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action

Fig. 4

Dasatinib blocks the TGF-β1-induced generation of cells with stem cell character. a Panc-1 cells were treated or not for 14 d with TGF-β1 (5 ng/ml) and either DMSO or dasatinib (10 μM) followed by qPCR-based determination of the indicated stem cell-associated genes. Data are plotted relative to untreated DMSO-treated control cells and represent the mean ± SD from three independent experiments. Asterisks indicate a significant difference between the DMSO + TGF-β1 and the dasatinib + TGF-β1 treated cells (n = 3). b Panc-1 cells were treated or not for 14 d with TGF-β1 (5 ng/ml) and either DMSO, dasatinib (10 μM), or SB431542 (5 μM) followed by colony formation assay. Data represent the mean ± SD from three independent assays. Asterisks indicate a significant difference relative to the non-TGF-β1-treated control cells (n = 3)

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Molecular Cancer

ISSN: 1476-4598