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Fig. 7 | Molecular Cancer

Fig. 7

From: Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells

Fig. 7

External nucleotide levels create a pro-metastatic microenvironment in irradiated organs. Panel a. Detection of human lung cancer cells (HTB177) in liver, lung, and BM of mice irradiated and then inoculated with LC cells. HTB177 cells before transplant were pretreated with PSB603 (1 μM) or vehicle. Five mice were employed per group, and results are shown as means ± SEM. *p < 0.05. Panel b. Detection of human lung cancer cells (HTB177) in liver, lung, and BM of mice irradiated and then inoculated with LC cells. HTB177 cells before transplant were pretreated with iso-PPADS (10 μM) or vehicle. Five mice were employed per group, and results are shown as means ± SEM. *p < 0.05. Panel c. Radiochemotherapy induces release of EXNs that may be reponsible for the metastatic spread of LC cells that survived the initial tretament

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Molecular Cancer

ISSN: 1476-4598