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Fig. 1 | Molecular Cancer

Fig. 1

From: Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model

Fig. 1

Ad-OSM and NDV-OSM replicate in human and hamster PDAC cells. a Schematic representation of the main viruses used in this study. ITR, adenovirus inverted terminal repeat; ΔE1A 922–947 indicates the nucleotides deleted from the E1A gene; ΔE3 6.7/gp19K indicates the deletion of these genes in the E3 region; GFP, enhanced green fluorescence protein; TK, thymidine kinase from HSV-1; NP, P, M, F, HN and L are NDV genes. b-e Quantification of infectious particles produced at the indicated times in PANC-1 and HaP-T1 cells infected with the different viruses (representative results of at least 2 experiments performed in triplicate). Black columns correspond to cells treated with the hypoxia-mimetic drug CoCl2. * p <0.05, ** p <0.01

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Molecular Cancer

ISSN: 1476-4598