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Fig. 2 | Molecular Cancer

Fig. 2

From: Enhanced therapeutic effect using sequential administration of antigenically distinct oncolytic viruses expressing oncostatin M in a Syrian hamster orthotopic pancreatic cancer model

Fig. 2

NDV-OSM shows stronger oncolytic effect than Ad-OSM on PDAC cells in vitro. a Percentage of transduced (GFP+) HaP-T1 cells 24 h after infection with Ad-GFP and NDV-GFP at the indicated MOIs. b-d cells were infected at different MOIs (X-axis, logarithmic scale) and the percentage of viable cells remaining in the monolayer was quantified 5 days later by crystal violet staining (representative results of at least 2 experiments with 4 samples per point). Uninfected cells were used as a reference (100 % survival). e HaP-T1 cells were co-infected with equal MOIs of Ad-OSM and NDV-OSM, or infected with NDV-OSM only. The change in cytotoxic effect (enhancement or inhibition) is represented as a positive or negative percentage, respectively, considering 0 the value obtained by single NDV-OSM infection at each MOI

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Molecular Cancer

ISSN: 1476-4598