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Fig. 2 | Molecular Cancer

Fig. 2

From: Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma

Fig. 2

Hyperactivated mTOR signaling induces p53 and apoptosis in acinar cells. (a-c) Representative IHC pictures show in vivo activation of p53, apoptosis (cleaved-caspase 3), increased proliferation (p-Histone H3 (p-HH3)) in pancreatic tissues from Tsc1 -/- mice, scale bar: 50 μm; (d) Quantification of p-HH3-positive cells in Tsc1 -/- (n = 4) and Tsc1 -/+ (n = 4) pancreata; *: p < 0.05

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