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Fig. 4 | Molecular Cancer

Fig. 4

From: Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer

Fig. 4

Zinc transporter proteins are differentially expressed in MCF10A, T47D, and MDA-MB-231 cells. a Representative immunoblots of ZnT proteins detected in MCF10A, T47D, and MDA-MB-231 cells. Suitable antibodies for ZnT7 were not identified. B-actin was used as a normalization control. Images from different immunoblots or images from different parts of the same immunoblot are separated by dividing lines (for visual consistency). The major isoform was used for quantification. Data represent mean Zn transporter: β-actin ± SD, n = 2-3 for each cell line/experiment; each experiment was conducted 2–5 times. Asterisk denotes a significant difference from MCF10A cells, *p < 0.05. ND, not detected. b Representative immunoblots of ZIP proteins detected in MCF10A, T47D, and MDA-MB-231 cells. Suitable antibodies for ZIP2 and ZIP9 were not identified. ZIP13 was not expressed in MCF10A, T47D or MDA-MB-231 cells, but was detected in HC11 cells (data not shown). Data represent mean Zn transporter:β-actin ± SD, n = 2-3 samples/cell line/experiment and each experiment was conducted 2–5 times. Asterisk denotes a significant difference from MCF10A cells, p < 0.05. ND, not detected

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