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Table 1 Summary of altered piRNA expression in cancer

From: Piwi-interacting RNAs in cancer: emerging functions and clinical utility

Cancer Type piRNA ID Alteration Detection method Ref.
Breast piR-4987 upregulated deep sequencing of matched tumour-normal tissues, validated via PCR [73]
piR-20365
piR-20485
piR-20582
piR-34736 downregulated small RNAseq of cell lines and tumour biopsies (PCR validation of piRNA biogenesis proteins only) [74]
piR-36249
piR-35407
piR-36318
piR-34377
piR-36743 upregulated
piR-36026
piR-31106
Breast (CD44+/CD24−) piR-932 upregulated piRNA microarray of tumour tissue [75]
Gastric piR-823 downregulated piRNA microarray of cell lines, validated via PCR [76]
piR-651a upregulated piRNA microarray of matched tumour-normal tissues, validated via PCR [77]
piR-59056 upregulated Small RNAseq of matched tumour and normal tissues [78]
piR-32105
piR-58099
Kidney piR-32051 upregulated Small RNAseq of tumour tissue, validated via PCR [79]
piR-39894
piR-43607
piR-57125 downregulated in non-metastatic vs normal; downregulated in metastatic vs non-metastatic piRNA microarray of matched tumour-normal tissues, validated via PCR [80]
piR-38756 downregulated in non-metastatic vs normal; upregulated in metastatic vs non-metastatic
piR-30924
Liver piR-Hep1 upregulated deep sequencing of cell lines, validated in matched tumour-normal tissues via PCR [81]
Pancreas piR-017061 downregulated small RNAseq of tumour and normal tissue [83]
Multiple Myeloma piR-823 upregulated piRNA microarray of tumour and normal tissue, validated via PCR [84]
Lung piR-L-163 downregulated small RNAseq of NSCLC cell lines [62]
  1. aalso upregulated in colon, lung, and breast cancer tissue and hepatic carcinoma, mesothelioma, cervical, breast, and lung cancer cell lines