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Table 1 Summary of altered piRNA expression in cancer

From: Piwi-interacting RNAs in cancer: emerging functions and clinical utility

Cancer Type

piRNA ID

Alteration

Detection method

Ref.

Breast

piR-4987

upregulated

deep sequencing of matched tumour-normal tissues, validated via PCR

[73]

piR-20365

piR-20485

piR-20582

piR-34736

downregulated

small RNAseq of cell lines and tumour biopsies (PCR validation of piRNA biogenesis proteins only)

[74]

piR-36249

piR-35407

piR-36318

piR-34377

piR-36743

upregulated

piR-36026

piR-31106

Breast (CD44+/CD24−)

piR-932

upregulated

piRNA microarray of tumour tissue

[75]

Gastric

piR-823

downregulated

piRNA microarray of cell lines, validated via PCR

[76]

piR-651a

upregulated

piRNA microarray of matched tumour-normal tissues, validated via PCR

[77]

piR-59056

upregulated

Small RNAseq of matched tumour and normal tissues

[78]

piR-32105

piR-58099

Kidney

piR-32051

upregulated

Small RNAseq of tumour tissue, validated via PCR

[79]

piR-39894

piR-43607

piR-57125

downregulated in non-metastatic vs normal; downregulated in metastatic vs non-metastatic

piRNA microarray of matched tumour-normal tissues, validated via PCR

[80]

piR-38756

downregulated in non-metastatic vs normal; upregulated in metastatic vs non-metastatic

piR-30924

Liver

piR-Hep1

upregulated

deep sequencing of cell lines, validated in matched tumour-normal tissues via PCR

[81]

Pancreas

piR-017061

downregulated

small RNAseq of tumour and normal tissue

[83]

Multiple Myeloma

piR-823

upregulated

piRNA microarray of tumour and normal tissue, validated via PCR

[84]

Lung

piR-L-163

downregulated

small RNAseq of NSCLC cell lines

[62]

  1. aalso upregulated in colon, lung, and breast cancer tissue and hepatic carcinoma, mesothelioma, cervical, breast, and lung cancer cell lines