From: Piwi-interacting RNAs in cancer: emerging functions and clinical utility
Cancer Type | piRNA ID | Alteration | Detection method | Ref. |
---|---|---|---|---|
Breast | piR-4987 | upregulated | deep sequencing of matched tumour-normal tissues, validated via PCR | [73] |
piR-20365 | ||||
piR-20485 | ||||
piR-20582 | ||||
piR-34736 | downregulated | small RNAseq of cell lines and tumour biopsies (PCR validation of piRNA biogenesis proteins only) | [74] | |
piR-36249 | ||||
piR-35407 | ||||
piR-36318 | ||||
piR-34377 | ||||
piR-36743 | upregulated | |||
piR-36026 | ||||
piR-31106 | ||||
Breast (CD44+/CD24−) | piR-932 | upregulated | piRNA microarray of tumour tissue | [75] |
Gastric | piR-823 | downregulated | piRNA microarray of cell lines, validated via PCR | [76] |
piR-651a | upregulated | piRNA microarray of matched tumour-normal tissues, validated via PCR | [77] | |
piR-59056 | upregulated | Small RNAseq of matched tumour and normal tissues | [78] | |
piR-32105 | ||||
piR-58099 | ||||
Kidney | piR-32051 | upregulated | Small RNAseq of tumour tissue, validated via PCR | [79] |
piR-39894 | ||||
piR-43607 | ||||
piR-57125 | downregulated in non-metastatic vs normal; downregulated in metastatic vs non-metastatic | piRNA microarray of matched tumour-normal tissues, validated via PCR | [80] | |
piR-38756 | downregulated in non-metastatic vs normal; upregulated in metastatic vs non-metastatic | |||
piR-30924 | ||||
Liver | piR-Hep1 | upregulated | deep sequencing of cell lines, validated in matched tumour-normal tissues via PCR | [81] |
Pancreas | piR-017061 | downregulated | small RNAseq of tumour and normal tissue | [83] |
Multiple Myeloma | piR-823 | upregulated | piRNA microarray of tumour and normal tissue, validated via PCR | [84] |
Lung | piR-L-163 | downregulated | small RNAseq of NSCLC cell lines | [62] |